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bioRxiv · 10.64898/2026.08.27.747601

Computational simulation reveals the critical role of spike-timing-dependent plasticity in synchrony

Abstract

Emerging research on desynchronization reveals strong relations to memory formation and recollection with much of the evidence originating from studies of the hippocampus, a brain region central to memory processing. However, growing evidence emphasizing the role of desynchronization is accompanied by challenges, most notably the synchronization/desynchronization conundrum. The conundrum arises from an apparent contradiction between learning and Shannon's information theory: spike-timing-dependent plasticity (STDP) acquires information via synchronized populational activity whereas information theory suggests that information channel is encoded through higher variability. Both frameworks are well-founded. Learning is widely accepted as the mathematical abstraction of STDP while Shannon's information theory showcases its power ubiquitously across fields from communication systems to neuroscience. Here, we propose that learning and Shannon's information theory are not necessarily opposing principles. Rather, learning plays a critical role in the process of synchronization and desynchronization. To justify our claim, we conduct computational simulations based on a Hodgkin-Huxley neuronal model coupled with NMDA, AMPA, and GABA synapses with inputs of biologically realistic spiking data. Our results show that enabling STDP significantly influences synchronization and desynchronization dynamics. Specifically, we find that STDP and desynchronization form a regulatory loop, in which STDP regulates the level of synchrony, and synchrony regulates subsequent learning strength. Further study reveals STDP is capable of switching neurons from synchronization to desynchronization. This framework mitigates the synchronization/desynchronization conundrum by clarifying the relationship between desynchronization and learning, and offers a new perspective on how synchrony contributes to memory formation and recollection.

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BibTeXRIS

Huang, Y., Lankarany, M., D'Eleuterio, G.. 2026-09-22. Computational simulation reveals the critical role of spike-timing-dependent plasticity in synchrony. https://doi.org/10.64898/2026.08.27.747601

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