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bioRxiv · 10.64898/2026.08.24.746779

Imipramine binds to Amyloid-beta(1-42) monomers in vitro, as shown by NMR spectroscopy.

Beham, J.·Johnson, N. R.·Vögeli, B.·Henen, M. A.·Vugmeyster, L.
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Abstract

Imipramine is known as an older generation tricyclic antidepressant drug. It has been identified in prior studies that imipramine blocks Apolipoprotein E4 (ApoE4)-induced amyloid-{beta}(A{beta}) aggregation and is associated with an improved AD diagnosis [Johnson et al. Alzheimers Research Therapy, 2022, 14, 88]. Using NMR methods such as 1H-1H NOESY and Saturation Transfer Difference Spectroscopy, we demonstrate the binding of A{beta} monomers to imipramine when the full-length A{beta} (1-42) sequence is considered. The more abundant but less toxic form, A{beta} (1-40) does not show interaction with imipramine.

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Beham, J., Johnson, N. R., Vögeli, B., Henen, M. A., Vugmeyster, L.. 2026-08-27. Imipramine binds to Amyloid-beta(1-42) monomers in vitro, as shown by NMR spectroscopy.. https://doi.org/10.64898/2026.08.24.746779

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