Long-term stability of cellular-resolution brain-computer interface recordings after stroke

Utzschmid, A.; Terlau, J.; Held, L. M.; Schiffl, L. F.; Chen, H.; Alkan, G.; Favero, P.; Wagner, A.; Gempt, J.; Meyer, B.; Jacob, S. N.

doi:10.64898/2026.08.09.742157

bioRxiv · 10.64898/2026.08.09.742157

Long-term stability of cellular-resolution brain-computer interface recordings after stroke

Utzschmid, A.·Terlau, J.·Held, L. M.·Schiffl, L. F.·Chen, H.·Alkan, G.·Favero, P.·Wagner, A.·Gempt, J.·Meyer, B.·Jacob, S. N.

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Abstract

Implantable brain-computer interfaces (iBCIs) with single-neuron resolution are showing great promise for restoring mobility and communication in individuals with spinal cord injury or motor neuron disease. Stroke is the most common cause of acquired brain injury and a major contributor to long-term disability, making chronic stroke a highly relevant indication for iBCIs. However, whether stable intracortical recordings can be obtained from the structurally lesioned human brain is unknown. We report recordings from four 64-channel microelectrode arrays implanted in a participant with chronic aphasia after a large left-hemispheric stroke. The arrays targeted right-hemispheric frontoparietal regions homotopic to the damaged left-hemispheric language network. Across 111 sessions spanning 1,240 days, unit yield and signal quality remained stable. Waveform-based tracking reliably identified individual units across sessions, including across extended recording gaps. Short- and long-term unit stability was comparable to previous reports from iBCI participants without structural brain lesions, and tracked units showed consistent spiking properties across sessions. Our findings provide the first evidence that single-neuron recordings can remain stable over the long term in the stroke-lesioned human brain. They establish the feasibility of chronic, cellular-resolution iBCIs after stroke and support the development of neurorestorative applications for deficits caused by structural brain injury.

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Utzschmid, A., Terlau, J., Held, L. M., Schiffl, L. F., Chen, H., Alkan, G., Favero, P., Wagner, A., Gempt, J., Meyer, B., Jacob, S. N.. 2026-08-18. Long-term stability of cellular-resolution brain-computer interface recordings after stroke. https://doi.org/10.64898/2026.08.09.742157

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