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bioRxiv · 10.64898/2026.08.02.742231

Reverse DTNB assay: a novel in vitrobiochemical approach to detect oxidized thiol modifications

Abstract

The participation of sulfhydryl or thiol functions in a multitude of protein posttranslational modifications, although reflects on the redox versatility of cysteine residues, but their assessment in a dynamic cellular milieu involving the facile inter-conversion of SH to SSG, S-S, SNO, and S-R has been overwhelmingly difficult despite theirimplications in protein folding, enzyme structure and function, signalling and detoxification pathways, and pathophysiological ramifications.The current methodology, in contrast to a wide variety of cumbersome and prolonged techniques,repurposes the conventional DTNB assay for a hassle-free qualitative and quantitative analysisof redox-modified single or multiple susceptible thiol residues of cysteines in pure proteins as well as in a complex mixture of proteins.In this study, we document the thiol content, bearing the susceptibility to undergo reversible, oxidative thiol modifications, utilizing reverse DTNB assay in cell-free lysates and purified proteins that might provide a possible framework for dissecting the physiological phenomena behind the concealment of the susceptible cysteines through their redox-modified forms.

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Choudhuri, A., Chakraborty, S., Mishra, A., Sengupta, R.. 2026-08-06. Reverse DTNB assay: a novel in vitrobiochemical approach to detect oxidized thiol modifications. https://doi.org/10.64898/2026.08.02.742231

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