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bioRxiv · 10.64898/2026.06.12.731865

The Amygdalostriatal Transition Area Exhibits Lateral Amygdala-Like Spiking Activity and Tone-Shock Pairing-Induced Plasticity

Abstract

During Pavlovian fear conditioning, presentation of a conditioned stimulus, such as a tone, together with an unconditioned stimulus, such as an electrical shock, excites neurons in the lateral amygdala (LA). Prevailing models propose that sensory stimulus-evoked activity in the LA is subsequently propagated to its downstream nuclei: the basal amygdala (BA) and central amygdala (CeA). To test this assumption, we performed in vivo electrophysiological recordings in awake, head-fixed male and female mice. We found that tone presentation did not elicit a significant increase in firing in BA or CeA neurons. In contrast, shock presentation evoked similarly robust spiking responses in LA and BA neurons but only a modest increase in CeA neurons. Notably, neurons in the amygdalostriatal transition area (AStria) exhibited LA-like sensory stimulus-evoked responses at both short (<25 ms) and longer (<500 ms) timescales. To examine the role of feedforward inhibition in tone- and shock-evoked activity, we investigated the contribution of parvalbumin interneurons using optogenetics and found that short-latency (<25 ms) spiking in both the LA and AStria was regulated by these inhibitory cells. Finally, LA and AStria neurons exhibited remarkably similar response types, spiking dynamics, and pairing-induced plasticity during repeated tone presentations, subsequent tone-shock pairings, and post-pairing tone presentations. Together, these findings support a model in which the LA and AStria operate in parallel, similarly integrating tone and shock signals during fear conditioning, whereas BA and CeA neurons are not robustly recruited by these sensory stimuli under the conditions tested.

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Magyar, D., Karlocai, M. R., Hajos, N.. 2026-06-13. The Amygdalostriatal Transition Area Exhibits Lateral Amygdala-Like Spiking Activity and Tone-Shock Pairing-Induced Plasticity. https://doi.org/10.64898/2026.06.12.731865

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