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bioRxiv · 10.64898/2026.05.31.729074

Quilting the Brain: Whole-Brain iEEG Reconstruction via Incomplete Observation Linear Mixed Models

Abstract

Mapping human brain function at high spatiotemporal resolution is constrained by the physical limitations of non-invasive imaging and the sparse sampling of invasive electrophysiology. While intracranial electroencephalography (iEEG) captures local eld potentials with millimeter precision, clinical implantation strategies result in a "coverage paradox" : observations are restricted to disjoint, patient-specific patches, leaving most of the cortex unobserved. This study introduces the Incomplete Observation Linear Mixed-Effect Model (IOLMM), a statistical framework that resolves this paradox by "quilting" fragmented observations into continuous, whole-brain source activity maps. Our approach integrates two innovations: (1) Sure Independence Screening (SIS) adapted from ultra-high-dimensional statistics to distinguish true physiological signals from volume-conducted "ghost sources"; (2) a hierarchical IOLMM that decouples group-level physiological fixed effects from subject-specific instrumental random effects, solving the scaling ambiguities that plague iEEG group analyses. Applied to the MNI Open iEEG Atlas, the framework is validated through sleep stage-dependent cortical source power reconstruction across Wake, N2, N3, and REM states, recovering the frontal predominance of NREM slow-wave activity and the graded electrophysiological hierarchy from fragmented recordings of 106 patients. This work establishes the first cortical surface-level normative electrophysiological atlas derived from iEEG, providing a quantitative reference for detecting and predicting epileptogenic lesions and bridging the gap between the microscopic precision of electrophysiology and the macroscopic scope of systems neuroscience. HighlightsO_LISolving the Coverage Paradox: A novel IOLMM statistical framework quilts sparse, non-overlapping iEEG data into a unified whole-brain probabilistic map. C_LIO_LIGeometric Screening: Adapts high-dimensional Sure Independence Screening (SIS) using cortical geometric eigenmodes to effectively filter out spurious ghost sources in inverse solutions. C_LIO_LIRobust Harmonization: Decouples group-level physiological fixed effects from subject-specific random effects, resolving scaling ambiguities inherent in heterogeneous multi-center recordings. C_LIO_LIBiological Validation: Validates the framework on real multi-center iEEG data by reconstructing sleep stage-dependent cortical source power maps, recovering known electrophysiological signatures of NREM and REM sleep from fragmented recordings. C_LI

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Wang, Y., Li, M., Bringas Vega, M. L., Valdes-Sosa, P. A.. 2026-06-03. Quilting the Brain: Whole-Brain iEEG Reconstruction via Incomplete Observation Linear Mixed Models. https://doi.org/10.64898/2026.05.31.729074

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