Simple synthesis and functionalisation of α-hydroxyglycine-containing peptide fragments

Solanke, P. R.; Sarkar, D.; Saha, P. C.; Taylor, M. T.

doi:10.64898/2026.05.29.728772

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bioRxiv · 10.64898/2026.05.29.728772

Simple synthesis and functionalisation of α-hydroxyglycine-containing peptide fragments

Solanke, P. R.·Sarkar, D.·Saha, P. C.·Taylor, M. T.

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Abstract

We report here a method for the chemical synthesis of Fmocprotected -hydroxyglyine (-OH-Gly) dipeptides. Our method features operational simplicity and is compatible with protecting groups for peptide synthesis. Utility is then demonstrated through substitution at the -OH-Gly position to yield myriad non-natural amino acid-containing dipeptide fragments.

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Solanke, P. R., Sarkar, D., Saha, P. C., Taylor, M. T.. 2026-06-02. Simple synthesis and functionalisation of α-hydroxyglycine-containing peptide fragments. https://doi.org/10.64898/2026.05.29.728772

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