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bioRxiv · 10.64898/2026.05.28.728511

GeneKnow: AI-powered literature synthesis for gene-context analysis

Zhang, H.·Zang, C.
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Abstract

Biological function is context dependent, yet synthesizing evidence for a genes function in a defined cell type, disease, or perturbation remains labor-intensive. Here we present GeneKnow, an auditable artificial intelligence (AI) framework for source-grounded biological evidence synthesis. GeneKnow separates evidence-critical operations, including literature retrieval, passage selection, provenance tracking, and bibliography construction, from generative steps that are constrained to semantic analysis and literature synthesis. GeneKnow supports multi-paper discovery and single-paper inspection while preserving links from synthesized claims to source passages, generating trustworthy syntheses without fabricated citations and minimizing hallucinations. Systematic benchmarking showed that GeneKnow achieved higher claim support and citation fidelity than leading general-purpose and scientific AI systems. These results demonstrate that an AI system with controlled division of labor between deterministic and generative components can substantially improve the fidelity and auditability of biomedical literature synthesis.

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Zhang, H., Zang, C.. 2026-06-01. GeneKnow: AI-powered literature synthesis for gene-context analysis. https://doi.org/10.64898/2026.05.28.728511

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