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bioRxiv · 10.64898/2026.05.23.727380

NeuroFate: endpoint-locked transcriptomic axis scoring for neurodegeneration risk research

Ghosh, N.·Sinha, K.
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Abstract

MotivationAD and PD transcriptomic cohorts can reveal disease-associated neuronal, glial, mitochondrial, myelin, proteostasis, vascular, and immune programs, but these signals are difficult to compare reproducibly across studies without endpoint-locked, sample-level biological summaries. ResultsWe present NeuroFate, a command-line research package that converts compact transcriptomic cohorts into curated neurodegeneration-axis scores, exploratory research-use risk scores, and conservative evidence reports. The software locks disease-state endpoints before scoring, maps genes or probes onto a 10-axis NeuroFate panel, records axis-gene coverage, and grades external cohort evidence by direction, effect size, nominal/FDR support, and claim-safety rules. Demonstrations across AD and PD resources show nominal independent AD support for a neuronal vulnerability axis, mixed PD convergence, and a PD-divergent synuclein-mitochondrial example while avoiding clinical or mechanism-overstating claims. Availability and implementationNeuroFate is implemented in Python and available at https://github.com/sinhakrishnendu/NeuroFate.git. Contactnabanitaghosh89@gmail.com; dr.krishnendusinha@gmail.com. Supplementary informationDocumentation, examples, tests, and reproducibility notes are included in the repository.

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Ghosh, N., Sinha, K.. 2026-05-27. NeuroFate: endpoint-locked transcriptomic axis scoring for neurodegeneration risk research. https://doi.org/10.64898/2026.05.23.727380

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