Shared book reading promotes experience-dependent autonomic synchrony in parent-preterm infant dyads

Lavezzo, L.; Meuleman, B.; Grandjean, D.; Gentaz, E.; Delplanque, S.; Ceravolo, L.; Scilingo, E. P.; Hüppi, P.; Barcos-Munoz, F.; Borradori-Tolsa, C.; Nardelli, M.; Filippa, M.

doi:10.64898/2026.05.19.726001

bioRxiv · 10.64898/2026.05.19.726001

Shared book reading promotes experience-dependent autonomic synchrony in parent-preterm infant dyads

Lavezzo, L.·Meuleman, B.·Grandjean, D.·Gentaz, E.·Delplanque, S.·Ceravolo, L.·Scilingo, E. P.·Hüppi, P.·Barcos-Munoz, F.·Borradori-Tolsa, C.·Nardelli, M.·Filippa, M.

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Abstract

Preterm birth is associated with alterations in early caregiver-infant regulation, with potential consequences for socio-emotional and physiological development. However, the mechanisms through which early interactional experience shapes these processes remain unclear. Here, we tested whether a structured dyadic intervention could modify co-regulatory dynamics across physiological, behavioral, and relational levels. Fifty-four 7-month-old preterm infants and their parents were assigned to either a shared book reading intervention (n = 22) or an active control condition based on a shared building activity (n = 32) and compared with 39 full-term infants. The intervention consisted of an 8-week program of shared book reading, designed to structure parent-infant interaction. Physiological synchrony was assessed at the dyadic level, alongside infants autonomic regulation and cardiovascular signal complexity. Behavioral engagement and parental attachment representations were also evaluated. Results showed that mother-infant physiological synchrony emerged selectively within the interactional context trained by the intervention and only in the intervention group. This context-specific synchrony was accompanied by modulation of vagal activity and increased cardiovascular complexity in preterm infants, consistent with enhanced flexibility of autonomic control. At the behavioral and relational levels, intervention infants showed increased initiating joint attention, while parents reported higher secure attachment. These findings support a model of experience-dependent early synchrony, in which repeated dyadic interaction through shared book reading shapes the coupling between interpersonal coordination and individual physiological regulation. By linking synchrony, autonomic flexibility, and social engagement, this study identifies a mechanism through which early caregiving experience can organize developmental trajectories following prematurity.

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Lavezzo, L., Meuleman, B., Grandjean, D., Gentaz, E., Delplanque, S., Ceravolo, L., Scilingo, E. P., Hüppi, P., Barcos-Munoz, F., Borradori-Tolsa, C., Nardelli, M., Filippa, M.. 2026-05-20. Shared book reading promotes experience-dependent autonomic synchrony in parent-preterm infant dyads. https://doi.org/10.64898/2026.05.19.726001

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