Investigating the Dynamic Relationship Between Anxiety and Spatial Memory Using Autonomous Ecological Momentary Assessment

Han, C. Z.; Zhao, K. C.; Wang, L. M.; Zhu, H.; Li, Y.; Kolibius, L. D.; Velazquez, A. G.; Song, Y. L.; Cami, A.; Carmona, J.; Hamberger, M.; Auerbach, R. P.; Schevon, C.; Jacobs, J.; Youngerman, B. E.

doi:10.64898/2026.05.15.725563

bioRxiv · 10.64898/2026.05.15.725563

Investigating the Dynamic Relationship Between Anxiety and Spatial Memory Using Autonomous Ecological Momentary Assessment

Han, C. Z.·Zhao, K. C.·Wang, L. M.·Zhu, H.·Li, Y.·Kolibius, L. D.·Velazquez, A. G.·Song, Y. L.·Cami, A.·Carmona, J.·Hamberger, M.·Auerbach, R. P.·Schevon, C.·Jacobs, J.·Youngerman, B. E.

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Abstract

Anxiety has been extensively studied in relation to memory, yet its dynamic association with spatial episodic memory in naturalistic clinical settings remains largely unexplored. We developed an anxiety-spatial-memory EMA protocol (asm-EMA) and deployed it in 30 epilepsy patients undergoing inpatient EEG monitoring, delivering combined momentary anxiety ratings and a validated spatial memory task pseudo-randomly every 90-150 minutes across multiple days. Subject-level asm-EMA means and session-to-session variability both correlated significantly with standard neuropsychological assessments, supporting the clinical validity of our design. Elevated within-person STAI-6 was selectively associated with faster retrieval responses, yet spatial memory accuracy was independent of all three anxiety measures, suggesting a shift in response strategy rather than memory impairment. Within-day anxiety showed short-term carryover between consecutive sessions, with little persistence beyond the next session. The asm-EMA protocol provides a feasible, autonomous framework for capturing moment-to-moment anxiety-memory dynamics in naturalistic settings.

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Han, C. Z., Zhao, K. C., Wang, L. M., Zhu, H., Li, Y., Kolibius, L. D., Velazquez, A. G., Song, Y. L., Cami, A., Carmona, J., Hamberger, M., Auerbach, R. P., Schevon, C., Jacobs, J., Youngerman, B. E.. 2026-05-16. Investigating the Dynamic Relationship Between Anxiety and Spatial Memory Using Autonomous Ecological Momentary Assessment. https://doi.org/10.64898/2026.05.15.725563

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