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bioRxiv · 10.64898/2026.05.06.723356

The Effect of Vaccination on the Evolution of the SARS-CoV-2 B.1.351 Variant

Wang, Z.·Raeihle, M.·Braun-Gorman, S.·Leung, I.·Richards, C.·Gabbay, L.·Shamoon-Pour, M.
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Abstract

Since the initial distribution of the SARS-CoV-19 vaccine, its widespread use has been hypothesized to act as a selective pressure that drives the COVID-19 virus to mutate. This study aims to investigate the correlation between global vaccination rates and the mutation rate of the SARS-CoV-2 Beta variant (B.1.351). From January to July 2021, nucleotide diversity increased in tandem with vaccination rates, demonstrating that the virus evolved more rapidly in response to selective pressure from mass vaccination. Statistical analysis revealed statistically significant positive correlations between both vaccination rates and vaccine doses administered with nucleotide diversity. Thus, our findings indicate a positive correlation between rising vaccination rates and nucleotide diversity, suggesting that increased vaccination coverage acted as a selective pressure that accelerated viral evolution of SARS CoV2.

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Wang, Z., Raeihle, M., Braun-Gorman, S., Leung, I., Richards, C., Gabbay, L., Shamoon-Pour, M.. 2026-05-08. The Effect of Vaccination on the Evolution of the SARS-CoV-2 B.1.351 Variant. https://doi.org/10.64898/2026.05.06.723356

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