Aberrant CD4+ T cell refeeding response impairs neuro-immune crosstalk in Parkinson's disease

Austin-Muttitt, K.; David, B. R.; Sassi, M.; Agarwal, R.; Sabedot, T.; Jones, J. R.; Cuoco, M. S.; Jenkins, B. J.; Roberts, L. D.; Harris, L.; Kieronczyk, N.; Han, G.; Hitchings, M. D.; Donaghy, P. C.; Yarnall, A. J.; Thornton, C. A.; Mohamed, B.; Morgan, A. H.; Thomas, F.; Jones, N.; Gage, F. H.; Davies, J. S.

doi:10.64898/2026.05.06.723248

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bioRxiv · 10.64898/2026.05.06.723248

Aberrant CD4+ T cell refeeding response impairs neuro-immune crosstalk in Parkinson's disease

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Abstract

T cells modulate disease associated neuroinflammation in Parkinsons disease (PD). We report that circulating CD4+ T cells from people with PD have a dysregulated transcriptional and cytokine response to fasting and refeeding and an altered metabolic profile. The CD4+ T cell secretome mediates a metabolic program in neurons that is impaired in PD, revealing dysfunctional neuro-immune signalling that may contribute to disease pathology.

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Austin-Muttitt, K., David, B. R., Sassi, M., Agarwal, R., Sabedot, T., Jones, J. R., Cuoco, M. S., Jenkins, B. J., Roberts, L. D., Harris, L., Kieronczyk, N., Han, G., Hitchings, M. D., Donaghy, P. C., Yarnall, A. J., Thornton, C. A., Mohamed, B., Morgan, A. H., Thomas, F., Jones, N., Gage, F. H., Davies, J. S.. 2026-05-11. Aberrant CD4+ T cell refeeding response impairs neuro-immune crosstalk in Parkinson's disease. https://doi.org/10.64898/2026.05.06.723248

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