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bioRxiv · 10.64898/2026.05.01.721793

Alternative respiratory electron transport pathways drive differential aminoglycoside susceptibility

Srivastav, S.·Karvannan, L.·Anand, A.
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Abstract

The bacterial electron transport system (ETS) is a highly branched and modular network that interfaces directly with the proton motive force (PMF) to drive ATP synthesis, solute transport, and cellular homeostasis (1-5). Distinct ETS branches differ in their capacities for proton translocation, redox balancing, and membrane polarization. The rewiring of cellular energetics has emerged as a recurrent strategy through which bacteria attenuate drug efficacy by shifting metabolic states, reducing membrane potential, and suppressing reactive oxygen species-linked killing mechanisms (6, 7). Here, we probe the interplay between respiratory routes and antibiotic susceptibilities.

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Srivastav, S., Karvannan, L., Anand, A.. 2026-05-02. Alternative respiratory electron transport pathways drive differential aminoglycoside susceptibility. https://doi.org/10.64898/2026.05.01.721793

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