Top-down regulation of ingestive behavior fragmentation

Qi, T.; Krull, C.; Leung, V. H.; Mardare, V.; Yang, D.; Lal, N.; Ma, J.; Wang, S.; Shen, H.; Zhang, A.; Zhao, B.; Heydari Seradj, S.; Korotkova, T.; Kennedy, A.; Ye, L.

doi:10.64898/2026.03.31.715709

bioRxiv · 10.64898/2026.03.31.715709

Top-down regulation of ingestive behavior fragmentation

Qi, T.·Krull, C.·Leung, V. H.·Mardare, V.·Yang, D.·Lal, N.·Ma, J.·Wang, S.·Shen, H.·Zhang, A.·Zhao, B.·Heydari Seradj, S.·Korotkova, T.·Kennedy, A.·Ye, L.

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Abstract

AbstractIn natural environments, animals rarely feed continuously to satiation; instead, feeding occurs in brief bouts separated by pauses. This fragmentation is thought to balance internal drives with external demands, yet its underlying neural mechanisms remain unclear. By combining bidirectional neural activity mapping and behavioral phenotyping, we identify a projection from the dorsal subiculum (dSub) of the hippocampus to the mammillary body (MB) as a key regulator of this fragmentation. Activity along the dSub-MB pathway tracks and gates the duration of individual feeding bouts, independent of homeostatic state. A simple bistable attractor model captures both dSub-MB neural dynamics and associated behaviors across optogenetic and behavioral perturbations. Together, these findings identify a top-down circuit mechanism that implements action selection in a naturalistic setting.

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Qi, T., Krull, C., Leung, V. H., Mardare, V., Yang, D., Lal, N., Ma, J., Wang, S., Shen, H., Zhang, A., Zhao, B., Heydari Seradj, S., Korotkova, T., Kennedy, A., Ye, L.. 2026-04-03. Top-down regulation of ingestive behavior fragmentation. https://doi.org/10.64898/2026.03.31.715709

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