A domain-general neural signature of serial order memory across action and perception

Abstract

Remembering events in the correct order, and generating ordered sequences of actions, are fundamental abilities across species. Behavioral studies, and theoretical work, raise the possibility that the brain represents serial order by a domain-general neural code, following the principle of Competitive Queuing. However, direct neurophysiological evidence for Competitive Queuing exists only in the motor domain. When humans and non-human primates prepare for a series of movements, several of the upcoming movements are represented in parallel, with their representational strength reflecting ordinal position in the sequence. We test the generalizability of this so-called primacy gradient across motor sequences and memorized auditory sequences. Using a multivariate decoding approach, Experiment 1 replicated the presence of a Competitive Queuing primacy gradient in magnetoencephalography (MEG) data of young healthy adults (n = 23) when they prepared a sequence of finger movements from memory. Importantly, we observed a similar primacy gradient when participants anticipated a sequence of tones they had learned before, in the absence of any movement. In Experiment 2 (n = 23; naive cohort), we rule out the possibility that this primacy gradient in auditory memory is explained by any learnt association between tones and movements, or by MEG signal fluctuations that are unrelated to discrete sequential events. In sum, we find a similar neural signature of serial order coding when humans prepare a sequence of movements, and when they anticipate a sequence of sounds. This lends support to the generalizability of Competitive Queuing.