Ultra-high field fMRI reveals functional patterns consistent with columnar organisation in human somatosensory cortex

Dempsey-Jones, H.; York, A.; Shaw, T. B.; Bollmann, S.; Barth, M.; Cunnington, R.; Puckett, A.

doi:10.64898/2026.03.24.712494

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bioRxiv · 10.64898/2026.03.24.712494

Ultra-high field fMRI reveals functional patterns consistent with columnar organisation in human somatosensory cortex

Dempsey-Jones, H.·York, A.·Shaw, T. B.·Bollmann, S.·Barth, M.·Cunnington, R.·Puckett, A.

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Abstract

In animal models, the primary somatosensory cortex (S1) exhibits columnar organisation, where vertically arranged neurons share functional properties. In humans, however, the thinness and folding of S1 have limited non-invasive investigations of such columnar structures. In this study, we aimed to identify columns in human S1 by delivering alternating bursts of 3 Hz and 30 Hz fingertip vibration while acquiring functional MRI time series at 7 Tesla. Using cortical surface modelling, we identified functional patterns in S1 that showed higher reliability, stronger differential responses, and greater statistical sensitivity than those observed in a frontal cortex control region (p = .001-.012 for reliability; p < .001 for differential signal; p = .004-.011 for sensitivity). Laminar analyses revealed depth-consistent frequency preferences in approximately 20-45% of S1 nodes, a pattern compatible with vertically organised functional structure. Although the relative signal difference between 3 Hz and 30 Hz was small (0.14% signal change), frequency tuning was reliably observed. Taken together, these findings reveal functional patterns in human S1 consistent with aspects of columnar-like organisation, providing non-invasive evidence of fine-scale functional architecture. TeaserfMRI reveals highly reliable but modestly selective responses in human S1, consistent with column-like functional organisation.

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Dempsey-Jones, H., York, A., Shaw, T. B., Bollmann, S., Barth, M., Cunnington, R., Puckett, A.. 2026-03-25. Ultra-high field fMRI reveals functional patterns consistent with columnar organisation in human somatosensory cortex. https://doi.org/10.64898/2026.03.24.712494

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