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bioRxiv · 10.64898/2026.03.03.709267

Individual-level metabolic connectivity captures cortical morphology and their coupling strengthens with age

Facca, M.·Tarricone, C.·Ridolfo, A.·Corbetta, M.·Vlassenko, A. G.·Goyal, M. S.·Bertoldo, A.
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Abstract

PurposeCerebral glucose metabolism and cortical morphology are known to undergo significant changes across the lifespan, yet their network-level coordination remains poorly understood. This study aimed to investigate whether individual-level metabolic connectivity (MC) reflects underlying inter-areal morphometric similarity, and to determine how this metabolic-morphometric coupling evolves across the adult lifespan. MethodsDynamic [18F]FDG-PET and structural MRI data were acquired from 67 healthy adults (age range: 38-86 years). Individual MC networks were estimated based on the similarity between regional time-activity curves. Corresponding structural similarity networks were generated using the morphometric inverse divergence (MIND) framework, which integrates multiple vertex-wise features of cortical morphology. The correspondence between metabolic and structural networks was quantified at both global and local scales using Spearman correlations. General linear models were employed to assess age-related effects on MC-MIND similarity. ResultsMC demonstrated a robust positive association with cortical morphometric similarity ({rho} = 0.32, p < 0.0001), an association that persisted after distance correction and was replicated at the individual level. Regional coupling followed a topographic gradient, peaking in heteromodal association cortices and reaching its minimum in paralimbic areas. Crucially, morphology-metabolism alignment systematically strengthened with age at the global level ({beta} = 0.59, p < 0.001). Local age-related increases were spatially heterogeneous, predominantly affecting visual, dorsal parietal, and premotor cortices alongside adjacent multimodal regions. ConclusionIndividual-level MC captures the morphometric organisation of the brain. The age-related increase in morphology-metabolism coupling indicates that metabolic coordination becomes progressively more aligned with cortical architecture, consistent with reduced neuroenergetic flexibility in the ageing brain.

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Facca, M., Tarricone, C., Ridolfo, A., Corbetta, M., Vlassenko, A. G., Goyal, M. S., Bertoldo, A.. 2026-03-04. Individual-level metabolic connectivity captures cortical morphology and their coupling strengthens with age. https://doi.org/10.64898/2026.03.03.709267

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