selscape: A Snakemake Workflow for Investigating Genomic Landscapes of Natural Selection

Chen, S.; Huang, X.

doi:10.64898/2026.02.28.708717

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bioRxiv · 10.64898/2026.02.28.708717

selscape: A Snakemake Workflow for Investigating Genomic Landscapes of Natural Selection

Chen, S.·Huang, X.

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Abstract

Analyzing natural selection is a central task in evolutionary genomics, yet applying multiple tools across populations in a reproducible and scalable manner is often complicated by heterogeneous input formats, parameter settings, and tool dependencies. Here, we present selscape, a Snakemake workflow that automates end-to-end genome-wide selection analysis--from input preparation and statistic calculation to functional annotation, downstream visualization, and summary reporting. We demonstrate selscape on high-coverage genomes from the 1000 Genomes Project, illustrating how the workflow enables efficient, large-scale analyses and streamlined comparisons across populations. By unifying diverse tools with Snakemake, selscape lowers the barrier to robust genome-wide analyses and provides a flexible framework for future extensions and integration with complementary population genetic analyses.

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Chen, S., Huang, X.. 2026-03-03. selscape: A Snakemake Workflow for Investigating Genomic Landscapes of Natural Selection. https://doi.org/10.64898/2026.02.28.708717

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