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bioRxiv · 10.64898/2026.02.27.708484

Preserved Intrinsic Neural Timescale Organization with Hierarchical Variation in Autism Spectrum Disorder

Abstract

Intrinsic neural timescales (INTs) index the temporal decay of neural activity and form a cortical hierarchy from fast sensorimotor to slow transmodal regions. Altered INTs have been reported in autism spectrum disorder (ASD), but it remains unclear whether the hierarchical organization is preserved and how individual variability along this hierarchy relates to sensory traits. Using resting-state fMRI from 182 participants (67 ASD, 115 typically developed controls (TDC)), we estimated INT at each cortical vertex from the autocorrelation half-life and averaged these values across four five-minute runs per participant. Vertex-wise INTs were then averaged within predefined cortical parcels and large-scale functional networks for subsequent analyses. The cortical INT hierarchy was preserved in ASD, showing comparable sensorimotor-to-transmodal hierarchy in both groups. However, regions operating at longer timescales showed prolonged INTs in ASD, and such tendency increased systematically along the hierarchy. No vertex, parcel, or network survived correction of multiple comparisons, indicating that observed alterations followed a distributed hierarchical trend rather than a focal pattern. To disentangle group-level differences from inter-individual variability, we next modeled each participants parcel-wise INT profile relative to a TDC-derived group-averaged template. At the individual level, decomposition of INT profiles revealed that global shifts and hierarchical scaling primarily reflected demographic variation (plimarily sex) rather than diagnostic group membership. After accounting for these components, residual deviations from theTDC-derived cortical INT hierarchy showed a modest association with sensory traits characterized by reduced sensory registration. Together, these findings indicate that while the large-scale hierarchical organization of cortical temporal dynamics is largely preserved in ASD, individual-specific deviations from this hierarchy may contribute to variability in sensory experience beyond group-level differences. HighlightsO_LIAcross both autism spectrum disorder (ASD) and typically developed controls (TDC), intrinsic neural timescales (INTs) followed the established sensory cortical hierarchy and showed a negative association with cortical microstructural markers (myelin content and neurite density index), with no group difference in hierarchical slope. C_LIO_LIAt the whole-brain level, the hierarchical organization of INTs was preserved across ASD and TDC, although regions operating at longer timescales exhibited relatively greater extension in ASD. C_LIO_LIGlobal shifts and hierarchical scaling, describing individual positioning within the INT-based cortical hierarchy, were more strongly associated with demographic variation (primarily sex) than with diagnosis. C_LIO_LIAfter accounting for these global and hierarchical components, residual deviations from the INT-based cortical hierarchy were modestly associated with sensory traits characterized by reduced sensory registration. C_LI

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Shikauchi, Y., Aoki, R., Itahashi, T., Shimizu, M., Naoe, T., Okimura, T., Ota, H., Hashimoto, R.-i., Nakamura, M.. 2026-02-27. Preserved Intrinsic Neural Timescale Organization with Hierarchical Variation in Autism Spectrum Disorder. https://doi.org/10.64898/2026.02.27.708484

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