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bioRxiv · 10.64898/2026.02.22.707205

Transcriptomic data of larval zebrafish exposed to continuous sub- and supra-MCL sodium arsenite and uranyl nitrate.

Kalaniopio, P. H.·Allen, R. S.·Salanga, M.
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Abstract

Uranium (U) and arsenic (As) are both ubiquitous contaminants in the American southwest, posing risks to humans, animals, and the environment. Depleted uraniums (DU) chronic effects and mechanisms of toxicity are incompletely understood. Differential gene expression of concomitant exposures to identify markers of toxicity have not been undertaken until now. Continuous low-dose, high-dose, and concomitant exposures are investigated using the larval zebrafish (Danio rerio), with exposure paradigms lasting from embryo collection until sampling at 5 days post fertilization (dpf). Herein, we describe overall differential gene expression with counts and pathway enrichment statistics using both gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. The raw dataset has been deposited in NCBIs Gene Expression Omnibus (GEO) repository [1] under the accession number GSE319292 [2]. O_TBL View this table: org.highwire.dtl.DTLVardef@9b121aorg.highwire.dtl.DTLVardef@c17073org.highwire.dtl.DTLVardef@1bdc2b9org.highwire.dtl.DTLVardef@13b130aorg.highwire.dtl.DTLVardef@15f1d22_HPS_FORMAT_FIGEXP M_TBL C_TBL VALUE OF THE DATAO_LIUranyl nitrate (UN), a water-soluble depleted uranium species, and sodium arsenite (As) are both ubiquitous contaminants in the American southwest, posing risks to humans, animals, and the environment. The United States Environmental Protection Agency (EPA) has set maximum contaminant limits (MCL) of 30 ppb U atoms and 10 ppb As atoms, respectively. C_LIO_LIThese data show differentially expressed genes (DEGs) from larval zebrafish exposed to 1 or 10 {micro}M As, 30 or 300 {micro}g/L UN, or 1 {micro}M As and 30 {micro}g/L UN in combination. Concentrations were specifically chosen based on environmental relevance. C_LIO_LIGene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of up- and down-regulated DEGs are provided to understand the molecular mechanisms of uranium toxicity and inform future studies. C_LIO_LIThese data should be used for biomarker identification and mechanistic interrogation of single and combinatorial exposures of environmentally relevant compounds at realistic exposure levels. C_LI

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Kalaniopio, P. H., Allen, R. S., Salanga, M.. 2026-02-23. Transcriptomic data of larval zebrafish exposed to continuous sub- and supra-MCL sodium arsenite and uranyl nitrate.. https://doi.org/10.64898/2026.02.22.707205

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