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bioRxiv · 10.64898/2026.01.27.701990

Experimental Trypanosoma cruzi infection cured with a mechanistically distinct drug combination

Francisco, A. F.·Olmo, F.·Escudie, F.·Chatelain, E.·Kelly, J. M.
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Abstract

Infections with the protozoan parasite Trypanosoma cruzi are widespread in the Americas and can lead to severe cardiac and/or gastrointestinal pathology. Current treatments are limited to monotherapies characterised by prolonged dosing regimens, disputed efficacy and toxic side-effects. Here, we demonstrate that short duration co-administration of well-tolerated sub-efficacious oral doses of the parasite-selective proteasome inhibitor GNF6702 and the pro-drug benznidazole produce parasitological cure in an experimental model of chronic Chagas disease.

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Francisco, A. F., Olmo, F., Escudie, F., Chatelain, E., Kelly, J. M.. 2026-01-27. Experimental Trypanosoma cruzi infection cured with a mechanistically distinct drug combination. https://doi.org/10.64898/2026.01.27.701990

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