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bioRxiv · 10.64898/2026.01.27.701946

Individual Dynamics in Stress-Related Pain Responses

Vyverman, J.·Timmers, I.·Meeuwis, S.·Smeets, T.·Hilger, K.
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Abstract

BackgroundStress and pain are adaptive, bidirectionally related systems, modulated by shared factors. However, how stress reactivity relates to individual differences in pain-related distress and pain sensitivity remains unclear. This preregistered study therefore investigates how physiological reactivity to acute stress relates to trait pain-related distress and stress-induced changes in pain sensitivity, and whether pain-related distress acts as moderator. MethodsTrait pain-related distress was assessed in 148 healthy males using questionnaires. Baseline blood pressure, pulse rate, alpha-amylase, and cortisol were obtained as well as initial heat pain thresholds and tolerances. One group underwent the Maastricht Acute Stress Task, while another group performed the placebo version. Consecutively all stress- and experimental pain indicators were examined again. ResultsTrait pain-related distress was not associated with stress reactivity (MAST-induced changes in physiological stress indicators), while stress-induced changes in pain sensitivity showed high individual variability, but were not associated with stress reactivity. Finally, we found preliminary evidence that in individuals with a higher tendency to catastrophize and to fear pain, stronger alpha-amylase increases were associated with larger stress-induced increases in pain threshold (p-FDR = .07). ConclusionOur study illustrates the idiosyncrasy of the complex interplay between trait pain-related distress, physiological stress reactivity, and stress-induced changes in pain sensitivity. While our preliminary results require replication, they suggest that stable individual differences influence the link between stress and pain beyond physiology. This underscores the importance of considering trait differences in future research on stress-pain interactions to, ultimately, better tailoring preventions and treatments for patients with chronic pain.

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Vyverman, J., Timmers, I., Meeuwis, S., Smeets, T., Hilger, K.. 2026-01-29. Individual Dynamics in Stress-Related Pain Responses. https://doi.org/10.64898/2026.01.27.701946

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