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bioRxiv · 10.64898/2026.01.23.701337

Neonatal brain-age models in full- and preterm infants

Abstract

Prematurity affects brain development and increases risk for neurodevelopmental impairments. Yet reliable biomarkers for at-risk infants remain limited. The goals of this study are (1a) to construct a white matter neonatal brain-age model including full-term and preterm neonates from a large publicly-available data set, (1b) to evaluate the accuracy of this model for characterizing the preterm brain from the same data set; (2) to determine if a similar model can predict brain-age based on clinical MRI scans from high-risk neonates born preterm; and (3) to evaluate whether this predictive model provides information about the infants health beyond conventional clinical and demographic measures. We developed brain-age prediction models using diffusion magnetic resonance imaging-derived white matter features from two datasets: (1) the developing Human Connectome Project (dHCP; 368 healthy infants) and (2) a clinical sample collected at the Lucile Packard Childrens Hospital (LPCH; 162 high-risk preterm infants). White matter features demonstrated strong predictive performance in the dHCP dataset (within 3.9 days) and the LPCH clinical dataset (within 6.6 days). However, brain-age metrics (i.e., brain-age gap) showed no significant associations with health complications measured by a composite score of common prematurity complications. While tractometry-derived brain-age models accurately characterize brain maturation in the neonatal brain, their sensitivity to clinical complications in preterm infants appears limited. Global white matter maturation measures derived from clinical grade data may be insufficiently sensitive to capture the cumulative burden of prematurity-related morbidities, suggesting need for multimodal or longitudinal biomarkers. HIGHLIGHTSBrain-age models of neonatal dMRI data predict age within days. Brain-age models of preterm infants predict post-menstrual age within a week. Brain-age models are accurate with research and clinical dMRI data in preterm infants. Brain-age gap was not sensitive to health status in a clinical preterm sample. GRAPHICAL ABSTRACT O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=79 SRC="FIGDIR/small/701337v1_ufig1.gif" ALT="Figure 1000"> View larger version (15K): org.highwire.dtl.DTLVardef@16f5c5dorg.highwire.dtl.DTLVardef@1918e0org.highwire.dtl.DTLVardef@1b0246eorg.highwire.dtl.DTLVardef@127f132_HPS_FORMAT_FIGEXP M_FIG C_FIG

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BibTeXRIS

Chiu, H., Richie-Halford, A., Lazarus, M. F., Rokem, A., Poblaciones, R. V., Marchman, V. A., Travis, K. E., Scala, M. L., Feldman, H. M., Yeatman, J. D.. 2026-01-23. Neonatal brain-age models in full- and preterm infants. https://doi.org/10.64898/2026.01.23.701337

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