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bioRxiv · 10.64898/2026.01.15.699687

Methyl Carnosate, a Carnosic Acid Derivative, Attenuates Osteoclastogenesis via Modulation of RANKL-Induced NF-κB Activity

Zhang, L.·Xie, C.·Bao, X.·Tabandeh, M.·Deepak, V.
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Abstract

Excessive osteoclast activity underlies bone-destructive diseases including osteoporosis and rheumatoid arthritis. RANKL-induced NF-{kappa}B signaling represents a critical pathway driving osteoclastogenesis. Here, we report that methyl carnosate, a naturally occurring diterpene from rosemary, inhibits RANKL-induced osteoclastogenesis with an IC50 of 1.2 M and displays greater potency than its parent compound, carnosic acid. Promoter-reporter analysis further indicates attenuation of RANKL-induced NF-{kappa}B activity. These findings identify methyl carnosate as a potential lead compound for the development of bone-protective therapeutics.

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Zhang, L., Xie, C., Bao, X., Tabandeh, M., Deepak, V.. 2026-01-15. Methyl Carnosate, a Carnosic Acid Derivative, Attenuates Osteoclastogenesis via Modulation of RANKL-Induced NF-κB Activity. https://doi.org/10.64898/2026.01.15.699687

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