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bioRxiv · 10.64898/2026.01.13.698266

What Is a Generative Model? Definitions, Disagreements, and Evaluation in Human Neuroimaging

Abstract

The term generative model is widely used in human neuroimaging; however, its meaning is often left implicit. Prompted by observations and discussions at the 2025 Organization for Human Brain Mapping (OHBM) Annual Meeting, we surveyed members of the neuroimaging community to examine how generative models are defined, used, and evaluated in practice. Responses revealed some agreement on functional criteria-- such as a models ability to simulate data--alongside marked disagreement about whether specific, widely used methods should be considered generative models. Evaluative priorities also varied across respondents, though out-of-sample generalization and interpretability were consistently emphasized. Rather than proposing a single definition, this perspective highlights the diversity of current usage and argues for greater clarity when the term is invoked.

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BibTeXRIS

Greaves, M. D., Novelli, L., Breakspear, M., Razi, A.. 2026-01-14. What Is a Generative Model? Definitions, Disagreements, and Evaluation in Human Neuroimaging. https://doi.org/10.64898/2026.01.13.698266

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