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bioRxiv · 10.64898/2025.12.22.696080

The geometry of cooperation: decoding microbial interactions

Abstract

Bridging the gap between mechanistic models of metabolism and ecological theory remains a key challenge in understanding interactions within microbial communities. We propose a geometric framework for analyzing community metabolism, based on constraint-based modeling. By extending pathway analysis methods from single organisms to multi-species systems, we define the community metabolic space as the set of all feasible fluxes between species and their environment, conditional on growth rate and medium composition. Embedded within a nonlinear geometry, this space forms a polytope whose vertices represent the minimal building blocks of community metabolism from which every feasible solution can be constructed. Strikingly, these elementary community flux modes invite direct ecological interpretation - as specialist, commensalist, or mutualist modes of cooperation. Furthermore, we find that mutualism is either isotypic (arising from a minimal mutualistic behavior) or anisotypic (emerging from a combination of reciprocal commensalists). This distinction demonstrates that bidirectional cross-feeding alone is insufficient to determine the ecological interaction type. Our framework also offers significant potential for applications. Because it does not rely on optimization, powerful unbiased tools from metabolic engineering, such as production envelopes and minimal cut sets, may be extended to microbial communities. Taken together, this perspective aims to unify ecological and metabolic viewpoints by linking interaction types to the geometric structure of the community metabolic space, thereby laying the foundation for a deeper understanding of community structure, function, and design.

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BibTeXRIS

Müller, S., Predl, M., Szeliova, D., Zanghellini, J.. 2025-12-27. The geometry of cooperation: decoding microbial interactions. https://doi.org/10.64898/2025.12.22.696080

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