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bioRxiv · 10.64898/2025.12.05.692661

A Comparative Evaluation of Adjuvants for Enhancing Antibody Responses to a Nanoparticle-Based Malaria Vaccine

Nepal, Y.·Francian, A.·Roberts, B. T.·Khan, R.·Wondra, G.·Apel, F.·Demierre, A.·Chackerian, B.
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Abstract

Effective pre-erythrocytic Plasmodium falciparum vaccines targeting circumsporozoite protein (CSP) must elicit strong and durable antibody responses. We assessed the ability of different classes of adjuvants to enhance immunity of a promising CSP-epitope-targeted virus-like particle (VLP)-based vaccine. Five formulations significantly increased anti-CSP IgG titers and several also enhanced antibody durability. This study identifies promising adjuvants that enhance both the magnitude and longevity of VLP-induced immunity.

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Nepal, Y., Francian, A., Roberts, B. T., Khan, R., Wondra, G., Apel, F., Demierre, A., Chackerian, B.. 2025-12-09. A Comparative Evaluation of Adjuvants for Enhancing Antibody Responses to a Nanoparticle-Based Malaria Vaccine. https://doi.org/10.64898/2025.12.05.692661

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