Anti-PD-1 treatment as a neurotherapy to enhance neuronal excitability, synaptic plasticity and memory

Zhao, J.; Ji, R. R.

doi:10.1101/870600

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bioRxiv · 10.1101/870600

Anti-PD-1 treatment as a neurotherapy to enhance neuronal excitability, synaptic plasticity and memory

Zhao, J.·Ji, R. R.

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Abstract

Emerging immunotherapy using anti-PD-1 antibodies have improved survival in cancer patients by immune activation. Here we show that functional PD-1 receptor is present in hippocampal CA1 neurons and loss of PD-1 or local anti-PD-1 treatment with nivolumab enhances neuronal excitability and long-term potentiation in CA1 neurons, leading to enhanced learning and memory. Our findings suggest that anti-PD-1 antibody also acts as a neurotherapy for improving memory and counteracting cognitive decline.

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Zhao, J., Ji, R. R.. 2019-12-10. Anti-PD-1 treatment as a neurotherapy to enhance neuronal excitability, synaptic plasticity and memory. https://doi.org/10.1101/870600

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