Hypoxia on vhl-deficient cells to obtain hif related genes through bioinformatics analysis.

Lin, H.; Liu, H.

doi:10.1101/863662

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bioRxiv · 10.1101/863662

Hypoxia on vhl-deficient cells to obtain hif related genes through bioinformatics analysis.

Lin, H.·Liu, H.

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Abstract

Vhl is responsible for degrading the transcription factor hif-1. Hif-1 transcription factors drive changes in hypoxic gene expression to adapt cells to exposure to hypoxic environments. This study hopes to analyze the effect of hypoxia on the vhl-deficient cells to obtain hif regulated genes through bioinformatics analysis. The top ten genes evaluated by connectivity degree in the PPI network were identified. CDK1, CTNNB1, NHP2, CCNA2, CTNNB1, MRPL16, CCND1 were down-regulated. CDK1, RPL12, RPL17, RPL27, RPS10 were up-regulated.

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Lin, H., Liu, H.. 2019-12-03. Hypoxia on vhl-deficient cells to obtain hif related genes through bioinformatics analysis.. https://doi.org/10.1101/863662

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