Development of a novel preclinical glioblastoma mouse model and therapeutic impact of IRE1 inhibition

Le Reste, P.-J.; Pineau, R.; Samal, J.; Jegou, G.; Lhomond, S.; Gorman, A. M.; Samali, A.; Patterson, J. B.; Zeng, Q.; Pandit, A.; AUBRY, M.; Soriano, N.; Etcheverry, A.; Mosser, J.; Avril, T.; chevet, e.

doi:10.1101/841296

bioRxiv · 10.1101/841296

Development of a novel preclinical glioblastoma mouse model and therapeutic impact of IRE1 inhibition

Le Reste, P.-J.·Pineau, R.·Samal, J.·Jegou, G.·Lhomond, S.·Gorman, A. M.·Samali, A.·Patterson, J. B.·Zeng, Q.·Pandit, A.·AUBRY, M.·Soriano, N.·Etcheverry, A.·Mosser, J.·Avril, T.·chevet, e.

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Abstract

Glioblastoma multiforme (GBM) is the most severe primary brain cancer. Despite an aggressive treatment comprising surgical resection and radio/chemotherapy patients survival post diagnosis remains short. A limitation for success in finding novel improved therapeutic options for such dismal disease partly lies in the lack of a relevant animal model that accurately recapitulates patient disease and standard of care. In the present study, we have developed a novel immunocompetent GBM model that includes tumor surgery and a radio/chemotherapy regimen resembling the Stupp protocol and we have used this model to test the impact of the pharmacological inhibition of the endoplasmic reticulum (ER) stress sensor IRE1, on treatment efficacy.

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Le Reste, P.-J., Pineau, R., Samal, J., Jegou, G., Lhomond, S., Gorman, A. M., Samali, A., Patterson, J. B., Zeng, Q., Pandit, A., AUBRY, M., Soriano, N., Etcheverry, A., Mosser, J., Avril, T., chevet, e.. 2019-11-14. Development of a novel preclinical glioblastoma mouse model and therapeutic impact of IRE1 inhibition. https://doi.org/10.1101/841296

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