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bioRxiv · 10.1101/839209

HIP IMO Report: Analyzing Phenotypic Properties of Bladder Cancer Using Ordinary Differential Equation (ODE) Models

Sherwin, B. C.
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Abstract

Bladder cancer is composed of proliferative and immunogenic phenotypes, which ultimately play a significant role in the growth of the tumor. By using ordinary differential equation models, this paper models the impact of high and low immunogenic cell populations on non-muscle invasive bladder cancer when treated with and without the Bacillus Calmette-Guerin vaccine. Furthermore, this paper models the impact that the Bacillus Calmette-Guerin vaccine has on inflammatory cytokines, which inhibit the growth of tumors by stimulating an immune response. We focus primarily on how the immunogenicity phenotype impacts population dynamics in non-muscle invasive bladder cancer.

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Sherwin, B. C.. 2019-11-12. HIP IMO Report: Analyzing Phenotypic Properties of Bladder Cancer Using Ordinary Differential Equation (ODE) Models. https://doi.org/10.1101/839209

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