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bioRxiv · 10.1101/833194

Immune cell-specific Cre reporter mouse labels a subset of CNS neurons

Bouteau, A.·Igyarto, B.
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Abstract

HuLangerin-Cre-YFPf/f mice were generated to specifically mark a subset of antigen presenting immune cells, called Langerhans cells (LCs). During histological characterization of these mice, we found that, in addition to LCs an uncharacterized cell population in the central nervous system (CNS) also expressed YFP. In this study, we found that the CNS YFP+ cells were negative for microglia and astrocyte markers, but they expressed mature neuronal marker NeuN and showed neuronal localization/morphology. Thus, these mice might be used to study the ontogeny, migration and the role of a subset of CNS neurons.

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Bouteau, A., Igyarto, B.. 2019-11-06. Immune cell-specific Cre reporter mouse labels a subset of CNS neurons. https://doi.org/10.1101/833194

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