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bioRxiv · 10.1101/819698

Ancient Yersinia pestis genomes provide no evidence for the origins or spread of the Justinianic Plague

Keller, M.·Spyrou, M. A.·McCormick, M.·Bos, K. I.·Herbig, A.·Krause, J.
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Abstract

Along with the publication of 137 ancient human genomes retrieved from archaeological remains of the Eurasian steppe, Damgaard et al., 2018 identified two individuals infected with Yersinia pestis, yielding one genome with 0.24x average coverage (DA147, 6th-9th c. AD) and another with 8.7x (DA101, 2nd-3rd c. AD). A phylogenetic analysis performed on the latter placed it in a position ancestral to a 6th-century Justinianic genome from Aschheim, Germany. These results are used to fuel an argument that the Justinianic Plague (541-544 AD) "was brought to Europe towards the end of the Hunnic period through the Silk Road along the southern fringes of the steppes" in contrast to the leading hypothesis of introduction via the Red Sea that is supported by historical accounts. In our reanalysis, we question the contested historical context of the presented genomes with the Justinianic Plague and show that the lower coverage genome might be rather related to the Black Death (1346-1353 AD).

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Keller, M., Spyrou, M. A., McCormick, M., Bos, K. I., Herbig, A., Krause, J.. 2019-10-31. Ancient Yersinia pestis genomes provide no evidence for the origins or spread of the Justinianic Plague. https://doi.org/10.1101/819698

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