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bioRxiv · 10.1101/793455

ProteoClade: a taxonomic toolkit for multi-species and metaproteomic analysis

Mooradian, A. D.·van der Post, S.·Naegle, K. M.·Held, J. M.
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Abstract

We present ProteoClade, a Python toolkit that performs taxa-specific peptide assignment, protein inference, and quantitation for multi-species proteomics experiments. ProteoClade scales to hundreds of millions of protein sequences, requires minimal computational resources, and is open source, multi-platform, and accessible to non-programmers. We demonstrate its utility for processing quantitative proteomic data derived from patient-derived xenografts and its speed and scalability enable a novel de novo proteomic workflow for complex microbiota samples.

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Mooradian, A. D., van der Post, S., Naegle, K. M., Held, J. M.. 2019-10-07. ProteoClade: a taxonomic toolkit for multi-species and metaproteomic analysis. https://doi.org/10.1101/793455

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