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bioRxiv · 10.1101/742577

Synaptic and intrinsic plasticity coordinate spike output in cerebellar Purkinje cells

Shim, H. G.·Kim, S. J.
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Abstract

Learning has been thought to be implemented by activity-dependent modifications of synaptic weight and intrinsic excitability. Here, we highlight how long-term depression at parallel fiber to Purkinje cell synapses (PF-PC LTD) and intrinsic plasticity of PCs coordinate the postsynaptic spike discharge from C57BL/6 male mice. Intrinsic plasticity of PCs in the flocculus matched the timing rules and shared intracellular signaling for PF-PC LTD. Notably, the intrinsic plasticity was confined to the dendritic branches where the synaptic plasticity is formed. Besides, when either synaptic or intrinsic plasticity was impaired, the impact of PF inputs was less reflected by the spike output of PCs. In conclusion, synergies between synaptic and intrinsic plasticity may play a role in tuning the PC output, thereby achieving optimal ranges of output.

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Shim, H. G., Kim, S. J.. 2019-08-21. Synaptic and intrinsic plasticity coordinate spike output in cerebellar Purkinje cells. https://doi.org/10.1101/742577

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