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bioRxiv · 10.1101/728600

Paternal Indifference and neglect in early life and Creativity: Exploring the Moderating Role of TPH1 genotype and Offspring’s Gender

Yu, Q.·Si, S.·Zhang, S.·Zhang, J.
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Abstract

For further understanding the joint contribution of environment, heredity and gender to creativity, the present research examined the prospective impact of paternal indifference & neglect in early life, TPH1 rs623580, offsprings gender, and the interaction effects thereof on creativity in five hundred and thirty-nine unrelated healthy Chinese undergraduate students. Paternal indifference & neglect in early life was assessed on the Parental Bonding Instrument (PBI) and creativity on the Runco Creativity Assessment Battery (rCAB). Results showed significant paternal indifference & neglect x TPH1 genotype and TPH1 genotype x offsprings gender interaction effects when predicting creativity. Specifically, paternal indifference & neglect in early life negatively predicted creativity in youth when individuals carry A allele of TPH1 (rs623580). In addition, male individuals who carry A allele were linked with lower level of flexibility compared to TT homozygote individuals. No significant three-way interaction was found. Findings from the current study suggested that the A allele of TPH1 (rs623580) might be a risk allele for creativity, and the long-term negative influence of paternal indifference & neglect in early life on individuals creativity in youth depending on TPH1 genotype.

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Yu, Q., Si, S., Zhang, S., Zhang, J.. 2019-08-08. Paternal Indifference and neglect in early life and Creativity: Exploring the Moderating Role of TPH1 genotype and Offspring’s Gender. https://doi.org/10.1101/728600

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