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bioRxiv · 10.1101/726950

Novel quinolone resistance determinant, qepA8, in Shigella flexneri isolated in the United States, 2016

Webb, H. E.·Tagg, K. A.·Chen, J. C.·Kim, J.·Lindsey, R. L.·Francois Watkins, L.·Karp, B. E.·Sugawara, Y.·Folster, J. P.
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Abstract

A qepA8+ Shigella flexneri was cultured from the stool of a traveler returning from India and East Asia. This chromosomally encoded qepA variant, has a six-base insertion, and may have been mobilized as part of a complex IS1-mediated composite transposon including catA1, aadA1, and blaOXA-1. In laboratory E. coli, qepA8 alone only conferred decreased ciprofloxacin susceptibility; however, it may work in combination with additional mechanisms to confer clinical resistance.

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Webb, H. E., Tagg, K. A., Chen, J. C., Kim, J., Lindsey, R. L., Francois Watkins, L., Karp, B. E., Sugawara, Y., Folster, J. P.. 2019-08-06. Novel quinolone resistance determinant, qepA8, in Shigella flexneri isolated in the United States, 2016. https://doi.org/10.1101/726950

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