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bioRxiv · 10.1101/718056

Metabolic control of immune-competency by odors in Drosophila

Madhwal, S.·Shin, M.·Joshi, M.·Kapoor, A.·Ur Rehman, P. M.·Gor, K.·Shim, J.·Mukherjee, T.
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Abstract

Drosophila blood-progenitor cells generate an inflammatory cell-type termed lamellocyte, in response to parasitic wasp-infections. In this study we show that olfaction primes lamellocyte potential. Specifically, larval odor-detection mediated release of systemic {gamma}-aminobutyric acid (GABA) from neurosecretory cells, is detected and internalized by blood progenitor-cells. GABA catabolism through the GABA-shunt pathway prevents Sima (HIF) protein degradation. Sima is necessary and sufficient for lamellocyte induction. However, limited systemic GABA availability during development restricts blood-progenitor Sima levels and consequently their lamellocyte potential. Preconditioning Drosophila larvae in odor environments mimicking parasitoid-threatened conditions raises systemic GABA and blood-progenitor Sima levels. As a result, infection responses in these animals are rapid and efficient. Overall, this study explores the importance of sensory control of myeloid-immunity and unravels the adaptive influence of environmental odor-experience on myeloid-metabolism and priming innate-immune potential.

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Madhwal, S., Shin, M., Joshi, M., Kapoor, A., Ur Rehman, P. M., Gor, K., Shim, J., Mukherjee, T.. 2019-07-30. Metabolic control of immune-competency by odors in Drosophila. https://doi.org/10.1101/718056

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