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bioRxiv · 10.1101/718015

Genetic overlap between psychotic experiences in the community across age and with psychiatric disorders

Barkhuizen, W.·Pain, O.·Dudbridge, F.·Ronald, A.
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Abstract

BackgroundThis study explores the degree to which genetic influences on psychotic experiences are stable across adolescence and adulthood, and their overlap with psychiatric disorders.\n\nMethodsGenome-wide association results were obtained for adolescent psychotic experiences and negative symptom traits (N = 6,297-10,098), schizotypy (N = 3,967-4,057) and positive psychotic experiences in adulthood (N = 116,787-117,794), schizophrenia (N = 150,064), bipolar disorder (N = 41,653) and depression (N = 173,005). Linkage disequilibrium score regression was used to estimate genetic correlations. Implicated genes from functional and gene-based analyses were compared. Mendelian Randomization was performed on trait pairs with significant genetic correlations.\n\nResultsSubclinical auditory and visual hallucinations and believing in conspiracies during adulthood were significantly genetically correlated with schizophrenia (rg = .27-.67) and major depression (rg = .41-.96) after correction for multiple testing. Auditory and visual subclinical hallucinations were highly genetically correlated (rg = .95). Cross-age genetic correlations for psychotic experiences were not significant. Gene mapping and gene association analyses revealed 14 possible genes associated with psychotic experiences that overlapped across age for psychotic experiences or between psychotic experiences and psychiatric disorders. Mendelian Randomization indicated bidirectional associations between auditory and visual hallucinations in adults but did not support causal relationships between psychotic experiences and psychiatric disorders.\n\nConclusionsPsychotic experiences in adulthood may be more linked genetically to schizophrenia and major depression than psychotic experiences in adolescence. Our study implicated specific genes that are associated with psychotic experiences across development as well as genes shared between psychotic experiences and psychiatric disorders.

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Barkhuizen, W., Pain, O., Dudbridge, F., Ronald, A.. 2019-07-29. Genetic overlap between psychotic experiences in the community across age and with psychiatric disorders. https://doi.org/10.1101/718015

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