Facile discovery of isonitrile natural products via tetrazine based click reactions

Huang, Y.; Cai, W.; Del Rio Flores, A.; Twiff, F. F.; Zhang, W.

doi:10.1101/711853

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bioRxiv · 10.1101/711853

Facile discovery of isonitrile natural products via tetrazine based click reactions

Huang, Y.·Cai, W.·Del Rio Flores, A.·Twiff, F. F.·Zhang, W.

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Abstract

A facile method for the quick discovery and quantification of isonitrile compounds from microbial cultures was established based on the isonitrile-tetrazine click reaction. A in situ reduction further enabled bioorthogonal ligation of primary and secondary isonitriles for the first time.

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Huang, Y., Cai, W., Del Rio Flores, A., Twiff, F. F., Zhang, W.. 2019-07-26. Facile discovery of isonitrile natural products via tetrazine based click reactions. https://doi.org/10.1101/711853

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