Functional cortico-subcortical reorganization after complete hemispheric disconnection for intractable epilepsy

Blauwblomme, T.; Demertzi, A.; Tacchela, J.-M.; Fillon, L.; Bourgeois, M.; Lositto, E.; Eisermann, M.; Marinazzo, D.; Raimondo, F.; Alcauter, S.; Van de Steen, F.; Colenbier, N.; Laureys, S.; Dangouloff-Ros, V.; Naccache, L.; Boddaert, N.; Nabbout, R.

doi:10.1101/707539

bioRxiv · 10.1101/707539

Functional cortico-subcortical reorganization after complete hemispheric disconnection for intractable epilepsy

Blauwblomme, T.·Demertzi, A.·Tacchela, J.-M.·Fillon, L.·Bourgeois, M.·Lositto, E.·Eisermann, M.·Marinazzo, D.·Raimondo, F.·Alcauter, S.·Van de Steen, F.·Colenbier, N.·Laureys, S.·Dangouloff-Ros, V.·Naccache, L.·Boddaert, N.·Nabbout, R.

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Abstract

Hemispherotomy is a treatment for drug-resistant epilepsy with the whole hemisphere involved in seizure onset. As recovery mechanisms are still debated, we characterize functional reorganization with multimodal MRI in two children operated on the right hemisphere (RH). We found that interhemispheric functional connectivity was abolished in both patients. The healthy left hemispheres (LH) displayed focal hyperperfusion in motor and limbic areas, and preserved network-level organization. The disconnected RHs were hypoperfused despite sustained network-level organization. Functional connectivity was increased in the left thalamo-cortical loop and between the cerebelli. The classification probability of the RH corresponding to a minimally conscious state was smaller than for the LH. We conclude that after hemispherotomy, neurological rehabilitation is sustained by cortical disinhibition and reinforcement of connectivity driven by subcortical structures in the remaining hemisphere. Our results highlight the effect of vascularization on functional connectivity and raise inquiries about the conscious state of the isolated hemisphere.

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Blauwblomme, T., Demertzi, A., Tacchela, J.-M., Fillon, L., Bourgeois, M., Lositto, E., Eisermann, M., Marinazzo, D., Raimondo, F., Alcauter, S., Van de Steen, F., Colenbier, N., Laureys, S., Dangouloff-Ros, V., Naccache, L., Boddaert, N., Nabbout, R.. 2019-07-19. Functional cortico-subcortical reorganization after complete hemispheric disconnection for intractable epilepsy. https://doi.org/10.1101/707539

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