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bioRxiv · 10.1101/701094

An updated analysis of opioids increasing the risk of fractures

Teng, Z.·Yue, Q.·Ma, Y.·Teng, Y.·Zhu, Y.·Liu, H.·Xu, S.·Liu, J.·Zhang, X.
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Abstract

ObjectiveTo assess the relationship between opioid therapy for chronic noncancer pain and fracture risk by a meta-analysis of cohort studies and case-control studies.\n\nMethodsThe included cohort studies and case-control studies were identified by searching the PubMed and EMBASE databases from their inception until May 24, 2019. The outcome of interest was a fracture. This information was independently screened by two authors. When the heterogeneity among studies was significant, a random effects model was used to determine the overall combined risk estimate.\n\nResultsIn total, 12 cohort studies and 6 case-control studies were included. We used the Newcastle-Ottawa Scale (NOS) to evaluate the quality of the included literature, and 14 of the studies were considered high-quality studies. The overall relative risk of opioid therapy and fractures was 1.78 (95% confidence interval (CI) 1.53 - 2.07). Subgroup analyses revealed sources of heterogeneity, sensitivity analysis was stable, and no publication bias was observed.\n\nConclusionsThe meta-analysis showed that the use of opioids significantly increased the risk of fracture.

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Teng, Z., Yue, Q., Ma, Y., Teng, Y., Zhu, Y., Liu, H., Xu, S., Liu, J., Zhang, X.. 2019-07-14. An updated analysis of opioids increasing the risk of fractures. https://doi.org/10.1101/701094

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