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bioRxiv · 10.1101/698464

Separating Measured Genetic and Environmental Effects: Evidence Linking Parental Genotype and Adopted Child Outcomes

Domingue, B. W.·Fletcher, J.
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Abstract

There has been widespread adoption of genome wide summary scores (polygenic scores) as tools for studying the importance of genetics and associated lifecourse mechanisms across a range of demographic and socioeconomic outcomes. However, an often unacknowledged issue with these studies is that parental genetics impact both child environments and child genetics, leaving the effects of polygenic scores difficult to interpret. This paper uses multi-generational data containing polygenic scores for parents (n=7,193) and educational outcomes for adopted (n=855) and biological (n=20,939) children, many raised in the same families, which allows us to separate the influence of parental polygenic scores on children outcomes between environmental (adopted children) and environmental and genetic (biological children) effects. Our results complement recent work on "genetic nurture" by showing associations of parental polygenic scores with adopted childrens schooling, providing additional evidence that polygenic scores combine genetic and environmental influences and that research designs are needed to separate these estimated impacts.

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Domingue, B. W., Fletcher, J.. 2019-07-11. Separating Measured Genetic and Environmental Effects: Evidence Linking Parental Genotype and Adopted Child Outcomes. https://doi.org/10.1101/698464

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