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bioRxiv · 10.1101/687376

Fecal Microbiota Transplantation Decreases Amyloid Load and Improves Cognition in Alzheimer’s

Elangovan, S.·Borody, T. J.·Holsinger, R. M. D.
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Abstract

The efficacy of fecal microbiota transplantation (FMT) in Alzheimers disease has yet to be investigated. Here, we show that FMT is capable of providing neuroprotective effects in two groups of treated 5xFAD Alzheimers mice, old transgenic (Tg) mice fed fecal slurry from healthy, wild-type donors of similar age (Old Tg-FO) and old mice fed fecal slurry from younger healthy, wild-type donors (Old Tg-FY). Improved spatial and recognition memory in Old Tg-FY and enhanced recognition memory in Old Tg-FO were observed when compared to Old Tg-Control mice given saline. Crucially, there was significant decreases in cortical A{beta} loading in all treated mice, demonstrating the therapeutic effects of FMT in improving cognition and reducing amyloid pathology in AD brains.\n\nOne Sentence SummaryFecal microbial transplants reduce amyloid pathology and improve cognition in Alzheimers mice.

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Elangovan, S., Borody, T. J., Holsinger, R. M. D.. 2019-07-01. Fecal Microbiota Transplantation Decreases Amyloid Load and Improves Cognition in Alzheimer’s. https://doi.org/10.1101/687376

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