Graph analytics for phenome-genome associations inference

Cirillo, D.; Garcia-Gasulla, D.; Cortes, U.; Valencia, A.

doi:10.1101/682229

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bioRxiv · 10.1101/682229

Graph analytics for phenome-genome associations inference

Cirillo, D.·Garcia-Gasulla, D.·Cortes, U.·Valencia, A.

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Abstract

MotivationBiological ontologies, such as the Human Phenotype Ontology (HPO) and the Gene Ontology (GO), are extensively used in biomedical research to find enrichment in the annotations of specific gene sets. However, the interpretation of the encoded information would greatly benefit from methods that effectively interoperate between multiple ontologies providing molecular details of disease-related features.\n\nResultsIn this work, we present a statistical framework based on graph theory to infer direct associations between HPO and GO terms that do not share co-annotated genes. The method enables to map genotypic features to phenotypic features thus providing a valid tool for bridging functional and pathological annotations. We validated the results by (a) supporting evidence of known drug-target associations (PanDrugs), protein-protein physical and functional interactions (BioGRID and STRING), and common pathways (Reactome); (b) comparing relationships inferred from early ontology releases with knowledge contained in the latest versions.\n\nApplicationsWe applied our method to improve the interpretation of molecular processes involved in pathological conditions, illustrating the applicability of our predictions with a number of biological examples. In particular, we applied our method to expand the list of relevant genes from standard functional enrichment analysis of high-throughput experimental results in the context of comorbidities between Alzheimers disease, Lung Cancer and Glioblastoma. Moreover, we analyzed pathways linked to predicted phenotype-genotype associations getting insights into the molecular actors of cellular senescence in Proteus syndrome.\n\nAvailabilityhttps://github.com/dariogarcia/phenotype-genotype_graph_characterization

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Cirillo, D., Garcia-Gasulla, D., Cortes, U., Valencia, A.. 2019-06-26. Graph analytics for phenome-genome associations inference. https://doi.org/10.1101/682229

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