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bioRxiv · 10.1101/674648

SOAPTyping: an open-source and cross-platform tool for Sanger sequence-based typing for HLA class I and II alleles

Zhang, Y.·Chen, Y.·Xu, H.·Fang, J.·Zhao, Z.·Hu, W.·Yang, X.·Ye, J.·Cheng, Y.·Wang, J.·Yang, H.·Yan, J.·Fang, L.
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Abstract

SummaryThe human leukocyte antigen (HLA) gene family plays a key role in the immune response and thus is crucial in many biomedical and clinical settings. Utilizing Sanger sequencing - the gold standard technology for HLA typing - enables accurate identification of HLA alleles with high-resolution. However, there exists a current hurdle that only commercial software such as UType, SBT-Assign and SBTEngine, instead of any open source tools could be applied to perform HLA typing based on Sanger sequencing. To fill the gap, we developed a stand-alone, open-source and cross-platform software, known as SOAPTyping, for Sanger-based typing in HLA class I and II alleles.\n\nAvailability and implementationSOAPTyping is implemented in C++ language and Qt framework, which is supported on Windows, Mac and Linux. Source code and detailed documentation are accessible via the project GitHub page: https://github.com/BGI-flexlab/SOAPTyping.\n\nContactfangl@genomics.cn\n\nSupplementary informationSupplementary data are available at Bioinformatics online.

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Zhang, Y., Chen, Y., Xu, H., Fang, J., Zhao, Z., Hu, W., Yang, X., Ye, J., Cheng, Y., Wang, J., Yang, H., Yan, J., Fang, L.. 2019-06-20. SOAPTyping: an open-source and cross-platform tool for Sanger sequence-based typing for HLA class I and II alleles. https://doi.org/10.1101/674648

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