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bioRxiv · 10.1101/673525

Estrogen induces mammary ductal dysplasia.

Itou, J.·Takahashi, R.·Sasanuma, H.·Tsuda, M.·Morimoto, S.·Matsumoto, Y.·Ishii, T.·Sato, F.·Takeda, S.·Toi, M.
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Abstract

Mammary ductal dysplasia is a phenotype observed in precancerous lesions and early-stage breast cancer. However, the mechanism of dysplasia formation remains elusive. Here we show, by establishing a novel dysplasia model system, that estrogen, a female hormone, has the potential to cause mammary ductal dysplasia. We injected estradiol (E2), the most active form of estrogen, daily into scid mice with a defect in nonhomologous end joining repair and observed dysplasia formation with cell proliferation at day 30. Moreover, we found that isoflavones inhibited E2-induced dysplasia formation. Our dysplasia model system provides insight into the mechanistic understanding of breast tumorigenesis, and the development of breast cancer prevention.

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Itou, J., Takahashi, R., Sasanuma, H., Tsuda, M., Morimoto, S., Matsumoto, Y., Ishii, T., Sato, F., Takeda, S., Toi, M.. 2019-06-18. Estrogen induces mammary ductal dysplasia.. https://doi.org/10.1101/673525

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