Women with isolated fasting hyperglycemia in pregnancy are at a higher genetic risk for type 2 diabetes

Abstract

BackgroundUsing genetic scores for fasting plasma glucose (FPG GS) and type 2 diabetes (T2D GS), we investigated whether the fasting, 1-hour and 2-hour glucose thresholds from the WHO 2013 criteria for gestational diabetes (GDM) have different implications for genetic susceptibility to raised fasting glucose and type 2 diabetes in women from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) and Atlantic Diabetes in Pregnancy (DIP) studies. MethodsCases were divided into three subgroups: (i) FPG [&ge;]5.1 mmol/L only, n=222; (ii) 1-hour glucose post 75 g oral glucose load [&ge;]10 mmol/L only, n=154 (iii) 2-hour glucose [&ge;]8.5 mmol/L only, n=73); and (iv) both FPG [&ge;]5.1 mmol/L and either of a 1-hour glucose [&ge;]10 mmol/L or 2-hour glucose [&ge;]8.5 mmol/L, n=172. We compared the FPG and T2D GS of these groups with controls (n=3,091) in HAPO and DIP separately. ResultsIn HAPO and DIP, the mean FPG GS in women with a FPG [&ge;]5.1 mmol/L, either on its own or with 1-hour glucose [&ge;]10 mmol/L or 2-hour glucose [&ge;]8.5 mmol/L, was higher than controls (all P <0.01). Mean T2D GS in women with a raised FPG alone or with either a raised 1-hour or 2-hour glucose was higher than controls (all P <0.05). GDM defined by 1-hour or 2-hour hyperglycaemia only was also associated with a higher T2D GS than controls (all P <0.05). ConclusionsThe different diagnostic categories that are part of the WHO 2013 criteria for GDM identify women with a genetic predisposition to type 2 diabetes as well as a risk for adverse pregnancy outcomes.