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bioRxiv · 10.1101/665539

Multimodal memory components and their long-term dynamics identified in cortical layers II/III but not layer Vb

Abstract

Activity patterns of cerebral cortical regions represent the present environment in which animals receive multi-modal inputs. They are also shaped by the history of previous activity that reflects learned information on past multimodal exposures. We studied the long-term dynamics of cortical activity patterns during the formation of multimodal memories by analysing in vivo high-resolution 2-photon mouse brain imaging of Immediate Early Gene expression, resolved by cortical layers. Strikingly, in layers II/III, the patterns showed similar dynamics across functional distinct cortical areas and the consistency of dynamic patterns lasts for one to several days. In contrast, in layer Vb, the activity dynamics varied across functional distinct areas, and the present activities are sensitive to the previous activities at different time depending on the cortical locations, indicating that the information stored in the cortex at different time points is distributed across different cortical areas. These results suggest different roles of layer II/III and layer Vb neurons in the long-term multimodal perception of the environment.

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Li, D., Wang, G., Xie, H., Hu, Y., Guan, J.-S., Hilgetag, C. C.. 2019-06-08. Multimodal memory components and their long-term dynamics identified in cortical layers II/III but not layer Vb. https://doi.org/10.1101/665539

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